ea0020oc5.4 | Thyroid: Basic and Clinical | ECE2009
Schomburg Lutz
, Dumitrescu Alexandra M
, Liao Xiao-Hui
, Bin-Abbas Bassam
, Hoeflich Johanna
, Kohrle Josef
, Refetoff Samuel
Selenium (Se) is an essential trace element needed for the biosynthesis of selenoproteins. Biosynthesis of such proteins depends on the selenocysteine incorporation sequence binding protein 2 (SBP2), which represents a key trans-acting factor during the translation process. We recently described children with mutations in SBP2 gene who displayed an abnormal thyroid function test(s) and reduced selenoprotein concentrations. Now we aimed to improve selenoprotein biosynthesis and...